Integrin beta-5 is a protein that in humans is encoded by the ITGB5 gene.

Interactions

Integrin, beta 5 has been shown to interact with PTK2, Annexin A5 and PAK4.

Functions

ITGB5 encodes a subunit of integrin that can interact with several alpha chains to form a variety of integrin heterodimers. It also plays a potential role in intercellular communication during tumor progression and metastasis.

Clinical significance

Research

Elevated levels of ITGB5 have been found in patients with autosomal dominant osteopetrosis type II, a rare disease of bones.

Further reading

External links