Integrin alpha 4

ITGA4

Available structuresPDBOrtholog search:List of PDB id codes, , , ,

Available structures

PDBOrtholog search:

List of PDB id codes, , , ,

List of PDB id codes

, , , ,

Identifiers

Aliases, CD49D, IA4, integrin subunit alpha 4

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 2 (human)

Band 2q31.3 Start 181,457,202 bp

End181,538,940 bp

Gene location ( Mouse )

Chr.Chromosome 2 (mouse)

Band 2 C3|2 47.38 cM Start 79,085,770 bp

End79,163,467 bp

RNA expression pattern

HumanMouse (ortholog)monocyte bone marrow cell granulocyte appendix blood lymph node spleen trabecular bone secondary oocyte epithelium of colonblood spleen lumbar spinal ganglion mesenteric lymph nodes internal carotid artery external carotid artery muscle layer of urethra thymus granulocyte human fetus

Human Mouse (ortholog)

monocyte bone marrow cell granulocyte appendix blood lymph node spleen trabecular bone secondary oocyte epithelium of colonblood spleen lumbar spinal ganglion mesenteric lymph nodes internal carotid artery external carotid artery muscle layer of urethra thymus granulocyte human fetus

monocyte bone marrow cell granulocyte appendix blood lymph node spleen trabecular bone secondary oocyte epithelium of colon

blood spleen lumbar spinal ganglion mesenteric lymph nodes internal carotid artery external carotid artery muscle layer of urethra thymus granulocyte human fetus

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

CD49d is an integrin alpha subunit. It makes up half of the α4β1 lymphocyte homing receptor.

Function

The product of this gene belongs to the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes an alpha 4 chain. Unlike other integrin alpha chains, alpha 4 neither contains an I-domain, nor undergoes disulfide-linked cleavage. Alpha 4 chain associates with either beta 1 chain or beta 7 chain.

Interactions

CD49d has been shown to interact with LGALS8 and Paxillin.

External links

at the U.S. National Library of MedicineMedical Subject Headings(MeSH)
Info with links in the 2014-12-11 at theWayback Machine
Humangenome location andgene details page in theUCSC Genome Browser.
Overview of all the structural information available in thePDBforUniProt:(Human Integrin alpha-4) at thePDBe-KB.

Integrin alpha 4

Function

Interactions

See also

Further reading

External links