Integrin beta 3
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Integrin beta-3 (β3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes.
Structure and function
The ITGB3 protein product is the integrin beta chain beta 3. Integrins are integral cell-surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as well as cell-surface-mediated signaling.
Role in endometriosis
Defectively expressed β3 integrin subunit has been correlated with presence of endometriosis, and has been suggested as a putative marker of this condition.
Interactions
CD61 has been shown to interact with PTK2, ITGB3BP, TLN1 and CIB1.
See also
Further reading
External links
- at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Info with links in the 2014-12-11 at the Wayback Machine
- Human genome location and gene details page in the UCSC Genome Browser.