Interleukin 1 receptor, type I

IL1R1

Available structuresPDBOrtholog search:List of PDB id codes, , , ,

Available structures

PDBOrtholog search:

List of PDB id codes, , , ,

List of PDB id codes

, , , ,

Identifiers

Aliases, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80, Interleukin 1 receptor, type I, interleukin 1 receptor type 1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 2 (human)

Band 2q11.2-q12.1 Start 102,064,544 bp

End102,179,874 bp

Gene location ( Mouse )

Chr.Chromosome 1 (mouse)

Band 1 B|1 18.81 cM Start 40,225,080 bp

End40,317,257 bp

RNA expression pattern

HumanMouse (ortholog)palpebral conjunctiva tibia pericardium corpus epididymis decidua caput epididymis urethra vena cava visceral pleura parietal pleuraislet of Langerhans seminal vesicula umbilical cord skin of external ear medullary collecting duct aortic valve primary oocyte ciliary body tunica media of zone of aorta cumulus cell

Human Mouse (ortholog)

palpebral conjunctiva tibia pericardium corpus epididymis decidua caput epididymis urethra vena cava visceral pleura parietal pleuraislet of Langerhans seminal vesicula umbilical cord skin of external ear medullary collecting duct aortic valve primary oocyte ciliary body tunica media of zone of aorta cumulus cell

palpebral conjunctiva tibia pericardium corpus epididymis decidua caput epididymis urethra vena cava visceral pleura parietal pleura

islet of Langerhans seminal vesicula umbilical cord skin of external ear medullary collecting duct aortic valve primary oocyte ciliary body tunica media of zone of aorta cumulus cell

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Interleukin 1 receptor, type I (IL1R1) also known as CD121a (Cluster of Differentiation 121a), is an interleukin receptor. IL1R1 also denotes its human gene.

The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein is a receptor for interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and interleukin 1 receptor antagonist (IL1RA). It is an important mediator involved in many cytokine induced immune and inflammatory responses. This gene along with interleukin 1 receptor, type II (IL1R2), interleukin 1 receptor-like 2 (IL1RL2), and interleukin 1 receptor-like 1 (IL1RL1) form a cytokine receptor gene cluster in a region mapped to chromosome 2q12.

Interactions

Interleukin 1 receptor, type I has been shown to interact with PIK3R1, Myd88 and IL1RAP.

External links

at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Interleukin 1 receptor, type I

Interactions

See also

Further reading

External links