John F. D. Spence (2 October 1875 – 20 February 1946) was a British sailing competitor at the 1908 Summer Olympics. Sources also give his name as James Fleming Drever Spence.

He was a crew member on the Mouchette which finished second of two teams competing in the 12 metre class. At the time, only the helmsman and mate were awarded silver medals, while the crew received bronze medals. However, Spence is credited as having received a silver medal in the official Olympic database.

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