KATNB1

Identifiers

Aliases, KAT, LIS6, katanin regulatory subunit B1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 16 (human)

Band 16q21 Start 57,735,739 bp

End57,757,244 bp

Gene location ( Mouse )

Chr.Chromosome 8 (mouse)

Band 8|8 C5 Start 95,807,814 bp

End95,829,777 bp

RNA expression pattern

HumanMouse (ortholog)middle temporal gyrus right frontal lobe right uterine tube Brodmann area 23 oocyte prefrontal cortex primary visual cortex Brodmann area 9 endothelial cell Brodmann area 10seminiferous tubule spermatid spermatocyte yolk sac visual cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell granulocyte internal carotid artery

Human Mouse (ortholog)

middle temporal gyrus right frontal lobe right uterine tube Brodmann area 23 oocyte prefrontal cortex primary visual cortex Brodmann area 9 endothelial cell Brodmann area 10seminiferous tubule spermatid spermatocyte yolk sac visual cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell granulocyte internal carotid artery

middle temporal gyrus right frontal lobe right uterine tube Brodmann area 23 oocyte prefrontal cortex primary visual cortex Brodmann area 9 endothelial cell Brodmann area 10

seminiferous tubule spermatid spermatocyte yolk sac visual cortex primary visual cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell granulocyte internal carotid artery

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene.

Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases. KATNB1 is associated with microlissencephaly.

External links

human gene location in the UCSC Genome Browser.
human gene details in the UCSC Genome Browser.

KATNB1

Further reading

External links