Lysine-specific demethylase 6A

KDM6A

Available structuresPDBOrtholog search:List of PDB id codes,

Available structures

PDBOrtholog search:

List of PDB id codes,

List of PDB id codes

Identifiers

Aliases, KABUK2, UTX, bA386N14.2, lysine demethylase 6A

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.X chromosome (human)

Band Xp11.3 Start 44,873,188 bp

End45,112,779 bp

Gene location ( Mouse )

Chr.X chromosome (mouse)

Band X A1.2- A1.3|X 13.45 cM Start 18,028,814 bp

End18,146,175 bp

RNA expression pattern

HumanMouse (ortholog)secondary oocyte bone marrow cell left ovary monocyte skin of abdomen germinal epithelium ectocervix vagina epithelium of colon skin of legzygote secondary oocyte genital tubercle primary oocyte internal carotid artery tail of embryo lacrimal gland Rostral migratory stream maxillary prominence external carotid artery

Human Mouse (ortholog)

secondary oocyte bone marrow cell left ovary monocyte skin of abdomen germinal epithelium ectocervix vagina epithelium of colon skin of legzygote secondary oocyte genital tubercle primary oocyte internal carotid artery tail of embryo lacrimal gland Rostral migratory stream maxillary prominence external carotid artery

secondary oocyte bone marrow cell left ovary monocyte skin of abdomen germinal epithelium ectocervix vagina epithelium of colon skin of leg

zygote secondary oocyte genital tubercle primary oocyte internal carotid artery tail of embryo lacrimal gland Rostral migratory stream maxillary prominence external carotid artery

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Lysine-specific demethylase 6A also known as Ubiquitously transcribed tetratricopeptide repeat, X chromosome (UTX), is a protein which in humans is encoded by the KDM6A gene. It belongs to the 2-oxoglutarate (2OG)-dependent dioxygenase superfamily.

The Y-chromosome version of this gene is called UTY.

Function

UTX has been linked with demethylation of lysine residues on histone, in particular H3K27, resulting in a gene derepression, a potential means of regulating cellular metabolism.

Lysine-specific demethylase 6A

Function

See also

Further reading