Kentucky Route 78 (KY 78) is a 25.300-mile-long (40.716 km) state highway in Kentucky that runs from KY 49 in rural Casey County northwest of Liberty to U.S. Route 150 (US 150) southeast of Stanford via Hustonville and Stanford. Much of the route follows the old Cumberland Trail from Stanford, KY to Nashville, TN.

Major intersections

CountyLocationmikmDestinationsNotes
Casey0.0000.000KY 49Western terminus
4.1256.639KY 243 north (Little South Road)Southern terminus of KY 243
9.11914.676KY 906 southWest end of KY 906 overlap
9.30314.972KY 906 northEast end of KY 906 overlap
LincolnHustonville12.07719.436US 127
16.94127.264KY 198 southNorthern terminus of KY 198
19.95432.113KY 1194 westEastern terminus of KY 1194
21.33134.329KY 300 west (Knob Lick Road)West end of KY 300 overlap
Stanford22.16135.665KY 2319 west (Helm Street)Eastern terminus of KY 2319
22.19535.719KY 300 east (Danville Avenue)East end of KY 330 overlap
22.33635.946KY 1247 south (Somerset Street) / Mill StreetWest end of KY 1247 overlap
22.40936.064KY 1247 north (North Lancaster Street) / South Lancaster StreetEast end of KY 1247 overlap
22.98736.994US 27
25.30040.716US 150Eastern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi