KLF5

Available structuresPDBOrtholog search:List of PDB id codes

Available structures

PDBOrtholog search:

List of PDB id codes

Identifiers

Aliases, BTEB2, CKLF, IKLF, Kruppel-like factor 5 (intestinal), Kruppel like factor 5

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 13 (human)

Band 13q22.1 Start 73,054,976 bp

End73,077,541 bp

Gene location ( Mouse )

Chr.Chromosome 14 (mouse)

Band 14|14 E2.2 Start 99,536,127 bp

End99,552,472 bp

RNA expression pattern

HumanMouse (ortholog)epithelium of nasopharynx gingival epithelium human penis mucosa of pharynx amniotic fluid mucosa of nose mucosa of sigmoid colon nipple skin of abdomen olfactory zone of nasal mucosaleft colon crypt of lieberkuhn of small intestine gastrula mucosa of urinary bladder transitional epithelium of urinary bladder migratory enteric neural crest cell skin of external ear conjunctival fornix ileum Paneth cell

Human Mouse (ortholog)

epithelium of nasopharynx gingival epithelium human penis mucosa of pharynx amniotic fluid mucosa of nose mucosa of sigmoid colon nipple skin of abdomen olfactory zone of nasal mucosaleft colon crypt of lieberkuhn of small intestine gastrula mucosa of urinary bladder transitional epithelium of urinary bladder migratory enteric neural crest cell skin of external ear conjunctival fornix ileum Paneth cell

epithelium of nasopharynx gingival epithelium human penis mucosa of pharynx amniotic fluid mucosa of nose mucosa of sigmoid colon nipple skin of abdomen olfactory zone of nasal mucosa

left colon crypt of lieberkuhn of small intestine gastrula mucosa of urinary bladder transitional epithelium of urinary bladder migratory enteric neural crest cell skin of external ear conjunctival fornix ileum Paneth cell

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Krueppel-like factor 5 is a protein that in humans is encoded by the KLF5 gene.

Function

This gene encodes a member of the Kruppel-like factor subfamily of zinc finger proteins. Since the protein localizes to the nucleus and binds the epidermal growth factor response element, it is thought to be a transcription factor.

Interactions

KLF5 has been shown to interact with Protein SET.

Clinical significance

KLF5 expression has been linked to higher survival rates for lung cancer patients.

External links

at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.