Left-right determination factor 1

LEFTY1

Identifiers

Aliases, LEFTB, LEFTYB, left-right determination factor 1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 1 (human)

Band 1q42.12 Start 225,886,282 bp

End225,911,382 bp

Gene location ( Mouse )

Chr.Chromosome 1 (mouse)

Band 1|1 H4 Start 180,762,587 bp

End180,765,965 bp

RNA expression patternHumanMouse (ortholog)mucosa of transverse colon body of pancreas rectum testicle gonad endometrium appendix epithelium of colon monocyte cerebellar hemisphereneural plate lateral plate mesoderm primitive endoderm Region I of hippocampus proper endothelial cell of lymphatic vessel lip ankle joint embryo islet of Langerhans skin of external earn/a

RNA expression pattern

HumanMouse (ortholog)mucosa of transverse colon body of pancreas rectum testicle gonad endometrium appendix epithelium of colon monocyte cerebellar hemisphereneural plate lateral plate mesoderm primitive endoderm Region I of hippocampus proper endothelial cell of lymphatic vessel lip ankle joint embryo islet of Langerhans skin of external ear

Human Mouse (ortholog)

mucosa of transverse colon body of pancreas rectum testicle gonad endometrium appendix epithelium of colon monocyte cerebellar hemisphereneural plate lateral plate mesoderm primitive endoderm Region I of hippocampus proper endothelial cell of lymphatic vessel lip ankle joint embryo islet of Langerhans skin of external ear

mucosa of transverse colon body of pancreas rectum testicle gonad endometrium appendix epithelium of colon monocyte cerebellar hemisphere

neural plate lateral plate mesoderm primitive endoderm Region I of hippocampus proper endothelial cell of lymphatic vessel lip ankle joint embryo islet of Langerhans skin of external ear

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Left-right determination factor 1 is a protein that in humans is encoded by the LEFTY1 gene.

Function

This gene encodes a member of the TGF-beta family of proteins. A similar secreted protein in mouse plays a role in left-right asymmetry determination of organ systems during development. Alternative processing of this protein can yield three different products. This gene is closely linked to both a related family member and a related pseudogene.

Left-right determination factor 1

Function

See also

Further reading