Lipoblast
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A lipoblast is a precursor cell for an adipocyte. Alternate terms include adipoblast and preadipocyte. Early stages are almost indistinguishable from fibroblasts.
- Lipoblasts (white arrow) and lipocytes (black arrow), in a case of lipoblastoma
- Micrograph showing a lipoblast (left-bottom of image) in a liposarcoma. H&E stain.
- Histopathology of liposarcoma, H&E stain, with the main features: - Spindle cells with enlarged, hyperchromatic nuclei. - Apparently univacuolated adipocytes (may look normal). - Lipoblasts (multivacuolated), but neither necessary nor sufficient for diagnosis of liposarcoma.
- Lipid-laden histiocytes may mimic lipoblasts, but have lightly eosinophilic cytoplasm and a small normochromatic nuclei which are not hollowed out from the lipid vacuoles.
Liposarcoma
Lipoblasts are seen in liposarcoma and characteristically have abundant multivacuolated clear cytoplasm and a dark staining (hyperchromatic), indented nucleus.