Louise Knak Lyksborg (born 17 January 1988) is a Danish former handball, who last played for Silkeborg-Voel KFUM and the Danish national team.

She started playing handball at the age of 7 in her local club Hillerød HK. In Denmark she played with GOG Håndbold, Lyngby HK and FC København Håndbold, before moving to German club HC Leipzig in 2010 on a 2-year deal. The club was at the time led by Danish coach Heine Jensen.

In 2016 she returned to Danish handball to join Silkeborg-Voel KFUM, where she played the rest of her career. She retired in 2019.