Protein mago nashi homolog is a human protein encoded by the MAGOH gene. This gene encodes the mammalian homolog of the Drosophila mago nashi gene. In mammals, mRNA expression is not limited to the germplasm, but is ubiquitous in adult tissues and can be induced by serum stimulation of quiescent fibroblasts.

In Drosophila

Drosophila flies produce unfit progeny when they have mutations in their mago nashi(Japanese: 孫なし, Hepburn: mago nashi; lit.'grandchildless') gene. The progeny have defects in germplasm assembly and germline development.

Interactions

MAGOH interacts with RBM8A and NXF1.

In Drosophila melanogaster, Mago Nashi and Tsunagi/Y14 are core components of the exon junction complex. They complex with novel zinc finger protein Ranshi, which is involved in oocyte differentiation.

Further reading