MAP3K10

Available structuresPDBOrtholog search:List of PDB id codes

Available structures

PDBOrtholog search:

List of PDB id codes

Identifiers

Aliases, MEKK10, MLK2, MST, mitogen-activated protein kinase kinase kinase 10

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 19 (human)

Band 19q13.2 Start 40,191,426 bp

End40,215,575 bp

Gene location ( Mouse )

Chr.Chromosome 7 (mouse)

Band 7|7 A3 Start 27,355,800 bp

End27,374,023 bp

RNA expression pattern

HumanMouse (ortholog)right frontal lobe prefrontal cortex cingulate gyrus anterior cingulate cortex amygdala beta cell nucleus accumbens putamen Brodmann area 9 right hemisphere of cerebellumsuperior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell muscle of thigh ventricular zone neural layer of retina cerebellar cortex spermatocyte ganglionic eminence ascending aorta

Human Mouse (ortholog)

right frontal lobe prefrontal cortex cingulate gyrus anterior cingulate cortex amygdala beta cell nucleus accumbens putamen Brodmann area 9 right hemisphere of cerebellumsuperior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell muscle of thigh ventricular zone neural layer of retina cerebellar cortex spermatocyte ganglionic eminence ascending aorta

right frontal lobe prefrontal cortex cingulate gyrus anterior cingulate cortex amygdala beta cell nucleus accumbens putamen Brodmann area 9 right hemisphere of cerebellum

superior frontal gyrus primary visual cortex dentate gyrus of hippocampal formation granule cell muscle of thigh ventricular zone neural layer of retina cerebellar cortex spermatocyte ganglionic eminence ascending aorta

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene.

Function

The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase has been shown to activate MAPK8/JNK and MKK4/SEK1, and this kinase itself can be phosphorylated, and thus activated by JNK kinases. This kinase functions preferentially on the JNK signaling pathway, and is reported to be involved in nerve growth factor (NGF) induced neuronal apoptosis.

Interactions

MAP3K10 has been shown to interact with:

MAP3K10

Function

Interactions

Further reading