MED25

Available structuresPDBOrtholog search:List of PDB id codes, , ,

Available structures

PDBOrtholog search:

List of PDB id codes, , ,

List of PDB id codes

, , ,

Identifiers

Aliases, ACID1, ARC92, CMT2B2, P78, PTOV2, BVSYS, TCBAP0758, mediator complex subunit 25

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 19 (human)

Band 19q13.33 Start 49,818,282 bp

End49,840,383 bp

Gene location ( Mouse )

Chr.Chromosome 7 (mouse)

Band 7 B3|7 28.95 cM Start 44,876,765 bp

End44,892,712 bp

RNA expression pattern

HumanMouse (ortholog)oocyte secondary oocyte right testis left testis right adrenal cortex right uterine tube left adrenal cortex blood muscle of thigh bronchial epithelial cellventricular zone muscle of thigh yolk sac dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex lip epiblast spermatid molar

Human Mouse (ortholog)

oocyte secondary oocyte right testis left testis right adrenal cortex right uterine tube left adrenal cortex blood muscle of thigh bronchial epithelial cellventricular zone muscle of thigh yolk sac dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex lip epiblast spermatid molar

oocyte secondary oocyte right testis left testis right adrenal cortex right uterine tube left adrenal cortex blood muscle of thigh bronchial epithelial cell

ventricular zone muscle of thigh yolk sac dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex lip epiblast spermatid molar

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Mediator of RNA polymerase II transcription subunit 25 is an enzyme that in humans is encoded by the MED25 gene.

Intellectual developmental disorder

A homozygous variant in the MED25 gene, leading to an arginine to trypsin substitution, was identified in seven individuals with impaired intellectual development and characteristic facial features. The genetic variant segregated with the disorder and was not found in control populations. This putative homozygous variant arose 218 years ago in this Brazilian family.

Interactions

MED25 has been shown to interact with MED4.

MED25

Intellectual developmental disorder

Interactions

Further reading

External links