ABCC4

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene.

ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors.

MRP4/ABCC4 expression is dysregulated in several cancers and is also upregulated in peritoneal endometriosis.

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles.

See also

• ATP-binding cassette transporter

Further reading

External links

• at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human genome location and gene details page in the UCSC Genome Browser.