Main Centre is a hamlet in the Canadian province of Saskatchewan. Listed as a designated place by Statistics Canada, the hamlet had a reported population of 5 living in 3 of its 4 total private dwellings in the Canada 2011 Census.

It is notable for being the birthplace of Homer Groening, the father of The Simpsons creator Matt Groening.

50°34′59″N 107°20′41″W/50.58306°N 107.34472°W/ 50.58306; -107.34472