NEK8

Identifiers

Aliases, JCK, NEK12A, NPHP9, RHPD2, NIMA related kinase 8

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 17 (human)

Band 17q11.2 Start 28,725,897 bp

End28,743,455 bp

Gene location ( Mouse )

Chr.Chromosome 11 (mouse)

Band 11 B5|11 46.74 cM Start 78,056,932 bp

End78,067,501 bp

RNA expression patternHumanMouse (ortholog)buccal mucosa cell left lobe of thyroid gland granulocyte right lobe of thyroid gland right uterine tube lymph node right adrenal cortex monocyte visceral pleura testiclesaccule otic vesicle lumbar spinal ganglion spermatocyte tail of embryo right kidney genital tubercle proximal tubule ventricular zone granulocyten/a

RNA expression pattern

HumanMouse (ortholog)buccal mucosa cell left lobe of thyroid gland granulocyte right lobe of thyroid gland right uterine tube lymph node right adrenal cortex monocyte visceral pleura testiclesaccule otic vesicle lumbar spinal ganglion spermatocyte tail of embryo right kidney genital tubercle proximal tubule ventricular zone granulocyte

Human Mouse (ortholog)

buccal mucosa cell left lobe of thyroid gland granulocyte right lobe of thyroid gland right uterine tube lymph node right adrenal cortex monocyte visceral pleura testiclesaccule otic vesicle lumbar spinal ganglion spermatocyte tail of embryo right kidney genital tubercle proximal tubule ventricular zone granulocyte

buccal mucosa cell left lobe of thyroid gland granulocyte right lobe of thyroid gland right uterine tube lymph node right adrenal cortex monocyte visceral pleura testicle

saccule otic vesicle lumbar spinal ganglion spermatocyte tail of embryo right kidney genital tubercle proximal tubule ventricular zone granulocyte

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase Nek8, also known as never in mitosis A-related kinase 8, is an enzyme that in humans is encoded by the NEK8 gene.

Function

Nek8 is a member of the serine/threonine-specific protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase.

Clinical significance

Mutations in the NEK8 gene associated with nephronophthisis.

NEK8

Function

Clinical significance

Further reading