NFATC1

Available structuresPDBOrtholog search:List of PDB id codes,

Available structures

PDBOrtholog search:

List of PDB id codes,

List of PDB id codes

Identifiers

Aliases, NF-ATC, NFAT2, NFATc, NF-ATc1.2, nuclear factor of activated T-cells 1, nuclear factor of activated T cells 1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 18 (human)

Band 18q23 Start 79,395,856 bp

End79,529,325 bp

Gene location ( Mouse )

Chr.Chromosome 18 (mouse)

Band 18 E3|18 53.66 cM Start 80,649,420 bp

End80,756,286 bp

RNA expression pattern

HumanMouse (ortholog)oocyte muscle of thigh secondary oocyte Skeletal muscle tissue of rectus abdominis triceps brachii muscle gastrocnemius muscle Skeletal muscle tissue of biceps brachii sural nerve glutes vastus lateralis musclegranulocyte mesenteric lymph nodes endocardial cushion triceps brachii muscle muscle of thigh olfactory epithelium knee joint temporal muscle blood ankle

Human Mouse (ortholog)

oocyte muscle of thigh secondary oocyte Skeletal muscle tissue of rectus abdominis triceps brachii muscle gastrocnemius muscle Skeletal muscle tissue of biceps brachii sural nerve glutes vastus lateralis musclegranulocyte mesenteric lymph nodes endocardial cushion triceps brachii muscle muscle of thigh olfactory epithelium knee joint temporal muscle blood ankle

granulocyte mesenteric lymph nodes endocardial cushion triceps brachii muscle muscle of thigh olfactory epithelium knee joint temporal muscle blood ankle

Gene ontologyMolecular functiontranscription factor activity, RNA polymerase II distal enhancer sequence-specific bindingCellular componentBiological processSources: /

Gene ontology

Molecular functiontranscription factor activity, RNA polymerase II distal enhancer sequence-specific binding

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)n/aLocation (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein) n/a

n/a

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Nuclear factor of activated T-cells, cytoplasmic 1 is a protein that in humans is encoded by the NFATC1 gene.

Function

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as ciclosporin. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes.

Interactions

NFATC1 has been shown to interact with PIM1.

External links

at the U.S. National Library of MedicineMedical Subject Headings(MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

NFATC1

Function

Interactions

See also

Further reading

External links