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Naked cuticle 1

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NKD1

Identifiers

Aliases, Naked1, Naked cuticle 1, naked cuticle homolog 1, WNT signaling pathway inhibitor, NKD inhibitor of WNT signaling pathway 1

External IDsOMIM: ; MGI: ; GeneCards:

Gene location ( Human )

Chr.Chromosome 16 (human)

Band 16q12.1 Start 50,548,396 bp

End50,649,249 bp

Gene location ( Mouse )

Chr.Chromosome 8 (mouse)

Band 8|8 C3 Start 89,247,982 bp

End89,321,512 bp

RNA expression patternHumanMouse (ortholog)right lung saphenous vein lateral nuclear group of thalamus popliteal artery tibial arteries endothelial cell sural nerve lower lobe of lung Descending thoracic aorta ascending aortazygote secondary oocyte gastrula tail of embryo primary oocyte left lung lobe Rostral migratory stream seminal vesicula lumbar subsegment of spinal cord genital tuberclen/a

RNA expression pattern

HumanMouse (ortholog)right lung saphenous vein lateral nuclear group of thalamus popliteal artery tibial arteries endothelial cell sural nerve lower lobe of lung Descending thoracic aorta ascending aortazygote secondary oocyte gastrula tail of embryo primary oocyte left lung lobe Rostral migratory stream seminal vesicula lumbar subsegment of spinal cord genital tubercle

Human Mouse (ortholog)

right lung saphenous vein lateral nuclear group of thalamus popliteal artery tibial arteries endothelial cell sural nerve lower lobe of lung Descending thoracic aorta ascending aortazygote secondary oocyte gastrula tail of embryo primary oocyte left lung lobe Rostral migratory stream seminal vesicula lumbar subsegment of spinal cord genital tubercle

right lung saphenous vein lateral nuclear group of thalamus popliteal artery tibial arteries endothelial cell sural nerve lower lobe of lung Descending thoracic aorta ascending aorta

zygote secondary oocyte gastrula tail of embryo primary oocyte left lung lobe Rostral migratory stream seminal vesicula lumbar subsegment of spinal cord genital tubercle

n/a

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsDatabasesNCBI: ; OMA:SpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

DatabasesNCBI: ; OMA:

Species Human Mouse

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

View/Edit HumanView/Edit Mouse

View/Edit HumanView/Edit Mouse

Naked cuticle homolog 1 (Naked-1) is a protein which in humans is encoded by the gene NKD1. Naked-1 is a member of the Naked cuticle (Nkd) family of proteins that regulate the Wnt signaling pathway. Nkd1 binds to the Dishevelled (Dvl) family of proteins (DVL1, DVL2, DVL3).

Species distribution

Insects typically have a single Nkd gene, whereas there are two Nkd genes, Nkd1 and Nkd2, in most vertebrates studied to date (zebrafish appear to have additional homologous genes such as Nkd3).

Clinical significance

Specific truncating NKD1 mutations identified in DNA mismatch repair deficient colon cancer that disrupt Nkd1/Dvl binding implicate these mutations as a cause of increased Wnt signaling in a subset of human colon cancers, the majority of which have increased Wnt signaling due to mutations the adenomatous polyposis coli (APC), AXIN2, or rarely the beta-catenin genes.