Neuronal PAS domain protein 4

NPAS4

Identifiers

Aliases, Le-PAS, NXF, PASD10, bHLHe79, neuronal PAS domain protein 4

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 11 (human)

Band 11q13.2 Start 66,421,004 bp

End66,426,707 bp

Gene location ( Mouse )

Chr.Chromosome 19 (mouse)

Band 19|19 A Start 5,034,383 bp

End5,040,344 bp

RNA expression patternHumanMouse (ortholog)pituitary gland anterior pituitary gonad left uterine tube body of uterus muscle layer of sigmoid colon gastric mucosa smooth muscle tissue popliteal artery tibial arteriesislet of Langerhans female urethra superior frontal gyrus primary visual cortex prefrontal cortex nucleus accumbens olfactory bulb dentate gyrus of hippocampal formation granule cell neural layer of retina cerebellar cortexn/a

RNA expression pattern

HumanMouse (ortholog)pituitary gland anterior pituitary gonad left uterine tube body of uterus muscle layer of sigmoid colon gastric mucosa smooth muscle tissue popliteal artery tibial arteriesislet of Langerhans female urethra superior frontal gyrus primary visual cortex prefrontal cortex nucleus accumbens olfactory bulb dentate gyrus of hippocampal formation granule cell neural layer of retina cerebellar cortex

Human Mouse (ortholog)

pituitary gland anterior pituitary gonad left uterine tube body of uterus muscle layer of sigmoid colon gastric mucosa smooth muscle tissue popliteal artery tibial arteriesislet of Langerhans female urethra superior frontal gyrus primary visual cortex prefrontal cortex nucleus accumbens olfactory bulb dentate gyrus of hippocampal formation granule cell neural layer of retina cerebellar cortex

pituitary gland anterior pituitary gonad left uterine tube body of uterus muscle layer of sigmoid colon gastric mucosa smooth muscle tissue popliteal artery tibial arteries

islet of Langerhans female urethra superior frontal gyrus primary visual cortex prefrontal cortex nucleus accumbens olfactory bulb dentate gyrus of hippocampal formation granule cell neural layer of retina cerebellar cortex

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Neuronal PAS domain protein 4 is a protein that in humans is encoded by the NPAS4 gene. The NPAS4 gene is a neuronal activity-dependent immediate early gene that has been identified as a transcription factor. The protein regulates the transcription of genes that control inhibitory synapse development, synaptic plasticity and most recently reported also behavior.

Function

NPAS4 is a member of the basic helix-loop-helix-PER-ARNT-SIM (bHLH-PAS) class of transcriptional regulators, which are involved in a wide range of physiologic and developmental events (Ooe et al., 2004 [PubMed 14701734]).[supplied by OMIM, Mar 2008].

NPAS4 has been shown to play critical roles in regulating the plasticity of inhibitory neurons. It was found that NPAS4 helps to regulate plasticity by orchestrating a redistribution of inhibitory synapses, wherein they are lost from proximal apical dendrites of CA1 pyramidal neurons and increased on the somata.

Neuronal PAS domain protein 4

Function

Further reading