Neuregulin 4

NRG4

Identifiers

Aliases, HRG4, neuregulin 4

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 15 (human)

Band 15q24.2 Start 75,935,969 bp

End76,059,795 bp

Gene location ( Mouse )

Chr.Chromosome 9 (mouse)

Band 9|9 B Start 55,127,506 bp

End55,234,128 bp

RNA expression patternHumanMouse (ortholog)body of pancreas right uterine tube cerebellar hemisphere right hemisphere of cerebellum secondary oocyte left testis olfactory zone of nasal mucosa right testis testicle muscle of thighzygote brown adipose tissue secondary oocyte Glandular part of endometrium white adipose tissue tunica adventitia of aorta subcutaneous adipose tissue intercostal muscle mammary gland primary oocyten/a

RNA expression pattern

HumanMouse (ortholog)body of pancreas right uterine tube cerebellar hemisphere right hemisphere of cerebellum secondary oocyte left testis olfactory zone of nasal mucosa right testis testicle muscle of thighzygote brown adipose tissue secondary oocyte Glandular part of endometrium white adipose tissue tunica adventitia of aorta subcutaneous adipose tissue intercostal muscle mammary gland primary oocyte

Human Mouse (ortholog)

body of pancreas right uterine tube cerebellar hemisphere right hemisphere of cerebellum secondary oocyte left testis olfactory zone of nasal mucosa right testis testicle muscle of thighzygote brown adipose tissue secondary oocyte Glandular part of endometrium white adipose tissue tunica adventitia of aorta subcutaneous adipose tissue intercostal muscle mammary gland primary oocyte

body of pancreas right uterine tube cerebellar hemisphere right hemisphere of cerebellum secondary oocyte left testis olfactory zone of nasal mucosa right testis testicle muscle of thigh

zygote brown adipose tissue secondary oocyte Glandular part of endometrium white adipose tissue tunica adventitia of aorta subcutaneous adipose tissue intercostal muscle mammary gland primary oocyte

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Neuregulin 4 also known as NRG4 is a member of the neuregulin protein family which in humans is encoded by the NRG4 gene.

Function

The neuregulins, including NRG4, activate erb-b2 receptor tyrosine kinase 4 (ERBB4) to initiating cell signaling through cytosolic tyrosine phosphorylation.

Clinical significance

Loss of expression of NRG4 is frequently seen in advanced bladder cancer while increased NRG4 expression correlates to better survival.

Neuregulin 4

Function

Clinical significance

Further reading