NWD1

Identifiers

Aliases, NACHT and WD repeat domain containing 1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 19 (human)

Band 19p13.11 Start 16,719,847 bp

End16,817,963 bp

Gene location ( Mouse )

Chr.Chromosome 8 (mouse)

Band 8|8 B3.3 Start 72,646,711 bp

End72,717,876 bp

RNA expression patternHumanMouse (ortholog)olfactory zone of nasal mucosa right uterine tube corpus callosum caudate nucleus nucleus accumbens temporal lobe amygdala putamen anterior cingulate cortex right frontal lobeolfactory epithelium Epithelium of choroid plexus lumbar subsegment of spinal cord substantia nigra dentate gyrus of hippocampal formation granule cell Rostral migratory stream primary visual cortex superior frontal gyrus cerebellar cortex hippocampus propern/a

RNA expression pattern

HumanMouse (ortholog)olfactory zone of nasal mucosa right uterine tube corpus callosum caudate nucleus nucleus accumbens temporal lobe amygdala putamen anterior cingulate cortex right frontal lobeolfactory epithelium Epithelium of choroid plexus lumbar subsegment of spinal cord substantia nigra dentate gyrus of hippocampal formation granule cell Rostral migratory stream primary visual cortex superior frontal gyrus cerebellar cortex hippocampus proper

Human Mouse (ortholog)

olfactory zone of nasal mucosa right uterine tube corpus callosum caudate nucleus nucleus accumbens temporal lobe amygdala putamen anterior cingulate cortex right frontal lobeolfactory epithelium Epithelium of choroid plexus lumbar subsegment of spinal cord substantia nigra dentate gyrus of hippocampal formation granule cell Rostral migratory stream primary visual cortex superior frontal gyrus cerebellar cortex hippocampus proper

olfactory zone of nasal mucosa right uterine tube corpus callosum caudate nucleus nucleus accumbens temporal lobe amygdala putamen anterior cingulate cortex right frontal lobe

olfactory epithelium Epithelium of choroid plexus lumbar subsegment of spinal cord substantia nigra dentate gyrus of hippocampal formation granule cell Rostral migratory stream primary visual cortex superior frontal gyrus cerebellar cortex hippocampus proper

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

NWD1, short for NACHT and WD repeat domain containing 1, is a gene found in vertebrates, which encodes a protein that contains a NACHT domain and a WD40 repeat domain. It was originally identified during a search for immune system genes in zebrafish as a protein coding sequence related to APAF1; orthologs were subsequently identified in mammalian species. The NWD1 gene of humans is located on chromosome 19. Current data suggests a causal role for tumor-associated over-expression of NWD1 in the dysregulation of androgen receptor signaling during prostate cancer progression.

NWD1

Further reading