One cut homeobox 1 is a protein that in humans is encoded by the ONECUT1 gene.

Function

This gene encodes a member of the Cut homeobox family of transcription factors. Expression of the encoded protein is enriched in the liver, where it stimulates transcription of liver-expressed genes, and antagonizes glucocorticoid-stimulated gene transcription. This gene may influence a variety of cellular processes including glucose metabolism, cell cycle regulation, and it may also be associated with cancer. It is important for the differentiation of pancreas endocrine cells, and mutations in ONECUT1 are involved in juvenile diabetes. Alternative splicing results in multiple transcript variants.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.