Hypocretin (orexin) receptor 1
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Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene.
Function
The orexin 1 receptor (OX1), is a G-protein coupled receptor that is heavily expressed in projections from the lateral hypothalamus and is involved in the regulation of feeding behaviour. OX1 selectively binds the orexin-A neuropeptide. It shares 64% identity with OX2.
Ligands
Agonists
Antagonists
- RTIOX-276 - Selective OX1 antagonist
- ACT-335827 - Selective OX1 antagonist
- Almorexant - Dual OX1 and OX2 antagonist
- Lemborexant - Dual OX1 and OX2 antagonist
- Nemorexant - Dual OX1 and OX2 antagonist
- SB-334,867 - Selective OX1 antagonist
- SB-408,124 - Selective OX1 antagonist
- SB-649,868 - Dual OX1 and OX2 antagonist
- Suvorexant - Dual OX1 and OX2 antagonist
See also
External links
- . IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. Archived from on 2016-02-06.
Further reading
This article incorporates text from the United States National Library of Medicine, which is in the public domain.