PAXIP1

Available structuresPDBOrtholog search:List of PDB id codes

Available structures

PDBOrtholog search:

List of PDB id codes

Identifiers

Aliases, CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2, CAGF28, PAX interacting protein 1

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 7 (human)

Band 7q36.2 Start 154,943,687 bp

End155,003,124 bp

Gene location ( Mouse )

Chr.Chromosome 5 (mouse)

Band 5 B1|5 13.23 cM Start 27,945,078 bp

End27,996,689 bp

RNA expression pattern

HumanMouse (ortholog)secondary oocyte cerebellar hemisphere ventricular zone right hemisphere of cerebellum corpus epididymis thymus cerebellar vermis cartilage tissue embryo ganglionic eminencetail of embryo genital tubercle epiblast ventricular zone zygote islet of Langerhans thymus otic placode spermatid primitive streak

Human Mouse (ortholog)

secondary oocyte cerebellar hemisphere ventricular zone right hemisphere of cerebellum corpus epididymis thymus cerebellar vermis cartilage tissue embryo ganglionic eminencetail of embryo genital tubercle epiblast ventricular zone zygote islet of Langerhans thymus otic placode spermatid primitive streak

secondary oocyte cerebellar hemisphere ventricular zone right hemisphere of cerebellum corpus epididymis thymus cerebellar vermis cartilage tissue embryo ganglionic eminence

tail of embryo genital tubercle epiblast ventricular zone zygote islet of Langerhans thymus otic placode spermatid primitive streak

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

PAX-interacting protein 1 is a protein that in humans is encoded by the PAXIP1 gene.

Function

This gene is a member of the paired box (PAX) gene family and encodes a nuclear protein with six BRCT (breast cancer carboxy-terminal) domains. This protein plays a critical role in maintaining genome stability, condensation of chromatin and progression through mitosis. Protein-affecting variants have also been implicated in Alzheimer's disease.

Interactions

PAXIP1 has been shown to interact with PAX2 and TP53BP1.

PAXIP1

Function

Interactions

Further reading