PCP4

Identifiers

Aliases, PEP-19, Purkinje cell protein 4

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 21 (human)

Band 21q22.2 Start 39,867,438 bp

End39,929,397 bp

Gene location ( Mouse )

Chr.Chromosome 16 (mouse)

Band 16 C4|16 56.97 cM Start 96,268,806 bp

End96,326,993 bp

RNA expression pattern

HumanMouse (ortholog)lateral nuclear group of thalamus external globus pallidus middle frontal gyrus Epithelium of choroid plexus putamen caudate nucleus nucleus accumbens seminal vesicula retinal pigment epithelium internal globus pallidusstriatum of neuraxis olfactory bulb cerebellum layer of retina neural layer of retina cerebellar cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell urinary bladder primary visual cortex

Human Mouse (ortholog)

lateral nuclear group of thalamus external globus pallidus middle frontal gyrus Epithelium of choroid plexus putamen caudate nucleus nucleus accumbens seminal vesicula retinal pigment epithelium internal globus pallidusstriatum of neuraxis olfactory bulb cerebellum layer of retina neural layer of retina cerebellar cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell urinary bladder primary visual cortex

striatum of neuraxis olfactory bulb cerebellum layer of retina neural layer of retina cerebellar cortex superior frontal gyrus dentate gyrus of hippocampal formation granule cell urinary bladder primary visual cortex

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Purkinje cell protein 4 is a protein that in humans is encoded by the PCP4 gene. Also known as PEP-19, PCP4 is a 7.6 kDa protein with an IQ-motif that binds to calmodulin (CaM). PCP4 is abundant in Purkinje cells of the cerebellum, and plays an important role in synaptic plasticity.

Function

PCP4 knockout mice have been reported to exhibit impaired locomotor learning and markedly altered synaptic plasticity in cerebellar Purkinje neurons. PCP4 accelerates both the association and dissociation of calcium (Ca2+) with calmodulin (CaM), which is postulated to influence the activity of CaM-dependent enzymes, especially CaM kinase II (CaMK-II).

PCP4

Function

Further reading