PEX14

Peroxisomal membrane protein PEX14 is a protein that in humans is encoded by the PEX14 gene.

Function

This gene encodes an essential component of the peroxisomal import machinery. The protein is integrated into peroxisome membranes with its C-terminus exposed to the cytosol, and interacts with the cytosolic receptor for proteins containing a PTS1 peroxisomal targeting signal. The protein also functions as a transcriptional corepressor and interacts with a histone deacetylase. A mutation in this gene results in one form of Zellweger syndrome.

Interactions

PEX14 has been shown to interact with

• PEX5,
• PEX7, and
• PEX13.

Further reading

External links

• Eukaryotic Linear Motif resource motif class
• Eukaryotic Linear Motif resource motif class
• Overview of all the structural information available in the PDB for UniProt: (Peroxisomal membrane protein PEX14) at the PDBe-KB.