Pleckstrin homology-like domain family A member 1 (PHLDA1) is a protein that in humans is encoded by the PHLDA1 gene.

This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1.

Interactions

PHLDA1 has been shown to interact with RPL14, EIF3D and PABPC4.

Further reading

  • Reddy PH, Stockburger E, Gillevet P, Tagle DA (1998). . Genomics. 46 (2): 174–82. doi:. PMID .
  • Kuske MD, Johnson JP (2000). "Assignment of the human PHLDA1 gene to chromosome 12q15 by radiation hybrid mapping". Cytogenet. Cell Genet. 89 (1–2): 1. doi:. PMID . S2CID .
  • Hinz T, Flindt S, Marx A, et al. (2001). "Inhibition of protein synthesis by the T cell receptor-inducible human TDAG51 gene product". Cell. Signal. 13 (5): 345–52. doi:. PMID .
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). . Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:. doi:. PMC . PMID .
  • Hossain GS, van Thienen JV, Werstuck GH, et al. (2003). . J. Biol. Chem. 278 (32): 30317–27. doi:. PMID .
  • Oberg HH, Sipos B, Kalthoff H, et al. (2005). . Cell Death Differ. 11 (6): 674–84. doi:. PMID .
  • Meier-Noorden M, Flindt S, Kalinke U, Hinz T (2004). "A CpG-rich bidirectional promoter induces the T-cell death-associated gene 51 and downregulates an inversely oriented transcript during early T-cell activation". Gene. 338 (2): 197–207. doi:. PMID .
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). . Genome Res. 14 (10B): 2121–7. doi:. PMC . PMID .
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:. doi:. PMID . S2CID .