Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the PPP2R1A gene. In the plant Arabidopsis thaliana a similar enzyme is encoded by the RCN1 gene (At1g25490).

Function

This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A.

Role in human pathology

Mutations of the PPP2R1A gene cause Houge-Janssens syndrome-2, an intellectual developmental disorder.

Interactions

PPP2R1A has been shown to interact with:

Arabidopsis RCN1

RCN1 At1g25490 is one of three genes in Arabidopsis encoding Phosphoprotein Phosphatase 2A Regulatory Subunit A (PP2Aa). The association of different b subunits with a PP2Aa-PP2ac dimer is believed to determine substrate specificity.

Further reading

  • Zolnierowicz S (2000). "Type 2A protein phosphatase, the complex regulator of numerous signaling pathways". Biochem. Pharmacol. 60 (8): 1225–1235. doi:. PMID .
  • Walter G, Ruediger R, Slaughter C, Mumby M (1990). . Proc. Natl. Acad. Sci. U.S.A. 87 (7): 2521–2525. Bibcode:. doi:. PMC . PMID .
  • Hemmings BA, Adams-Pearson C, Maurer F, Mueller P, Goris J, Merlevede W, Hofsteenge J, Stone SR (1990). "alpha- and beta-forms of the 65-kDa subunit of protein phosphatase 2A have a similar 39 amino acid repeating structure". Biochemistry. 29 (13): 3166–3173. doi:. PMID .
  • Walter G, Ferre F, Espiritu O, Carbone-Wiley A (1989). . Proc. Natl. Acad. Sci. U.S.A. 86 (22): 8669–8672. Bibcode:. doi:. PMC . PMID .
  • McCright B, Virshup DM (1995). . J. Biol. Chem. 270 (44): 26123–26128. doi:. PMID .
  • Ruediger R, Hentz M, Fait J, Mumby M, Walter G (1994). . J. Virol. 68 (1): 123–9. doi:. PMC . PMID .
  • Zolnierowicz S, Van Hoof C, Andjelković N, Cron P, Stevens I, Merlevede W, Goris J, Hemmings BA (1996). . Biochem. J. 317 (1): 187–94. doi:. PMC . PMID .
  • Tung HY, De Rocquigny H, Zhao LJ, Cayla X, Roques BP, Ozon R (1997). . FEBS Lett. 401 (2–3): 197–201. Bibcode:. doi:. PMID . S2CID .
  • Ruediger R, Brewis N, Ohst K, Walter G (1998). . Virology. 238 (2): 432–443. doi:. PMID .
  • Ruediger R, Fields K, Walter G (1999). . J. Virol. 73 (1): 839–42. doi:. PMC . PMID .
  • Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D (1999). . Cell. 96 (1): 99–110. doi:. PMID . S2CID .
  • Hong Y, Sarge KD (1999). . J. Biol. Chem. 274 (19): 12967–12970. doi:. PMID .
  • Yan Z, Fedorov SA, Mumby MC, Williams RS (2000). . Mol. Cell. Biol. 20 (3): 1021–1029. doi:. PMC . PMID .
  • Husi H, Ward MA, Choudhary JS, Choudhary JS, Blackstock WP (2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nat. Neurosci. 3 (7): 661–669. doi:. hdl:. PMID . S2CID .
  • Ruteshouser EC, Ashworth LK, Huff V (2001). . Oncogene. 20 (16): 2050–2054. doi:. PMID .
  • Lubert EJ, Hong Y, Sarge KD (2001). . J. Biol. Chem. 276 (42): 38582–38587. doi:. PMID .
  • Elder RT, Yu M, Chen M, Zhu X, Yanagida M, Zhao Y (2001). . Virology. 287 (2): 359–370. doi:. PMID .
  • Li X, Virshup DM (2002). . Eur. J. Biochem. 269 (2): 546–552. doi:. PMID .