PPP2R2B

Identifiers

Aliases, B55BETA, PP2AB55BETA, PP2ABBETA, PP2APR55B, PP2APR55BETA, PR2AB55BETA, PR2ABBETA, PR2APR55BETA, PR52B, PR55-BETA, PR55BETA, SCA12, protein phosphatase 2 regulatory subunit Bbeta

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 5 (human)

Band 5q32 Start 146,580,742 bp

End147,084,784 bp

Gene location ( Mouse )

Chr.Chromosome 18 (mouse)

Band 18|18 B3 Start 42,770,497 bp

End43,216,192 bp

RNA expression pattern

HumanMouse (ortholog)sperm ganglionic eminence prefrontal cortex caudate nucleus nucleus accumbens Brodmann area 23 putamen endothelial cell primary visual cortex dorsolateral prefrontal cortexentorhinal cortex perirhinal cortex neural layer of retina CA3 field primary motor cortex anterior amygdaloid area visual cortex primary visual cortex central gray substance of midbrain subiculum

Human Mouse (ortholog)

sperm ganglionic eminence prefrontal cortex caudate nucleus nucleus accumbens Brodmann area 23 putamen endothelial cell primary visual cortex dorsolateral prefrontal cortexentorhinal cortex perirhinal cortex neural layer of retina CA3 field primary motor cortex anterior amygdaloid area visual cortex primary visual cortex central gray substance of midbrain subiculum

sperm ganglionic eminence prefrontal cortex caudate nucleus nucleus accumbens Brodmann area 23 putamen endothelial cell primary visual cortex dorsolateral prefrontal cortex

entorhinal cortex perirhinal cortex neural layer of retina CA3 field primary motor cortex anterior amygdaloid area visual cortex primary visual cortex central gray substance of midbrain subiculum

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the PPP2R2B gene.

The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in the 5' UTR of this gene may cause a rare form of autosomal dominant spinocerebellar ataxia 12.

PPP2R2B

Further reading

External links