PREX2

Identifiers

Aliases, 6230420N16Rik, DEP.2, DEPDC2, P-REX2, PPP1R129, phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 8 (human)

Band 8q13.2 Start 67,952,046 bp

End68,237,032 bp

Gene location ( Mouse )

Chr.Chromosome 1 (mouse)

Band 1|1 A2 Start 11,063,689 bp

End11,373,905 bp

RNA expression patternHumanMouse (ortholog)Achilles tendon endothelial cell visceral pleura corpus callosum ventricular zone parietal pleura epithelium of colon adipose tissue subcutaneous adipose tissue caudate nucleusleft lung lobe lobe of cerebellum cerebellar vermis zygote sciatic nerve lateral septal nucleus tail of embryo otolith organ right lung utriclen/a

RNA expression pattern

HumanMouse (ortholog)Achilles tendon endothelial cell visceral pleura corpus callosum ventricular zone parietal pleura epithelium of colon adipose tissue subcutaneous adipose tissue caudate nucleusleft lung lobe lobe of cerebellum cerebellar vermis zygote sciatic nerve lateral septal nucleus tail of embryo otolith organ right lung utricle

Human Mouse (ortholog)

Achilles tendon endothelial cell visceral pleura corpus callosum ventricular zone parietal pleura epithelium of colon adipose tissue subcutaneous adipose tissue caudate nucleusleft lung lobe lobe of cerebellum cerebellar vermis zygote sciatic nerve lateral septal nucleus tail of embryo otolith organ right lung utricle

Achilles tendon endothelial cell visceral pleura corpus callosum ventricular zone parietal pleura epithelium of colon adipose tissue subcutaneous adipose tissue caudate nucleus

left lung lobe lobe of cerebellum cerebellar vermis zygote sciatic nerve lateral septal nucleus tail of embryo otolith organ right lung utricle

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2 is a protein that in humans is encoded by the PREX2 gene.

Clinical relevance

Mutations in this gene have been recurrently seen in melanoma.

PREX2

Clinical relevance

Further reading