PRKAA2

Available structuresPDBOrtholog search:List of PDB id codes, , , , , , ,

Available structures

PDBOrtholog search:

List of PDB id codes, , , , , , ,

List of PDB id codes

, , , , , , ,

Identifiers

Aliases, AMPK, AMPK2, AMPKa2, PRKAA, protein kinase AMP-activated catalytic subunit alpha 2

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

EC number

Gene location ( Human )

Chr.Chromosome 1 (human)

Band 1p32.2 Start 56,645,314 bp

End56,715,335 bp

Gene location ( Mouse )

Chr.Chromosome 4 (mouse)

Band 4|4 C6 Start 104,887,071 bp

End104,967,087 bp

RNA expression pattern

HumanMouse (ortholog)Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii right ventricle body of tongue renal medulla saphenous vein muscle of thigh vena cava Brodmann area 23triceps brachii muscle medial head of gastrocnemius muscle vastus lateralis muscle sternocleidomastoid muscle tibialis anterior muscle knee joint digastric muscle temporal muscle soleus muscle extraocular muscle

Human Mouse (ortholog)

Skeletal muscle tissue of rectus abdominis biceps brachii Skeletal muscle tissue of biceps brachii right ventricle body of tongue renal medulla saphenous vein muscle of thigh vena cava Brodmann area 23triceps brachii muscle medial head of gastrocnemius muscle vastus lateralis muscle sternocleidomastoid muscle tibialis anterior muscle knee joint digastric muscle temporal muscle soleus muscle extraocular muscle

triceps brachii muscle medial head of gastrocnemius muscle vastus lateralis muscle sternocleidomastoid muscle tibialis anterior muscle knee joint digastric muscle temporal muscle soleus muscle extraocular muscle

Gene ontologyMolecular functionkinase activity] kinase activity]Cellular componentBiological processSources: /

Gene ontology

Molecular functionkinase activity] kinase activity]

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene.

Function

The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.

PRKAA2

Function

Further reading