PTPN18

Available structuresPDBOrtholog search:List of PDB id codes, , ,

Available structures

PDBOrtholog search:

List of PDB id codes, , ,

List of PDB id codes

, , ,

Identifiers

Aliases, BDP1, PTP-HSCF, protein tyrosine phosphatase, non-receptor type 18, protein tyrosine phosphatase non-receptor type 18

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 2 (human)

Band 2q21.1 Start 130,356,045 bp

End130,375,405 bp

Gene location ( Mouse )

Chr.Chromosome 1 (mouse)

Band 1 B|1 13.25 cM Start 34,498,843 bp

End34,514,814 bp

RNA expression pattern

HumanMouse (ortholog)granulocyte monocyte right uterine tube mucosa of transverse colon rectum cerebellar hemisphere right hemisphere of cerebellum spleen tendon of biceps brachii body of pancreasgranulocyte thymus blood spleen mesenteric lymph nodes submandibular gland tibiofemoral joint duodenum lacrimal gland primary oocyte

Human Mouse (ortholog)

granulocyte monocyte right uterine tube mucosa of transverse colon rectum cerebellar hemisphere right hemisphere of cerebellum spleen tendon of biceps brachii body of pancreasgranulocyte thymus blood spleen mesenteric lymph nodes submandibular gland tibiofemoral joint duodenum lacrimal gland primary oocyte

granulocyte monocyte right uterine tube mucosa of transverse colon rectum cerebellar hemisphere right hemisphere of cerebellum spleen tendon of biceps brachii body of pancreas

granulocyte thymus blood spleen mesenteric lymph nodes submandibular gland tibiofemoral joint duodenum lacrimal gland primary oocyte

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 18 is an enzyme that in humans is encoded by the PTPN18 gene.

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-life. This gene was found to be expressed in brain, colon tissues, and several different tumor-derived cell lines. The biological function of this PTP has not yet been determined.

Interactions

PTPN18 has been shown to interact with PSTPIP1.

PTPN18

Interactions

Further reading