PTPRR

Available structuresPDBOrtholog search:List of PDB id codes

Available structures

PDBOrtholog search:

List of PDB id codes

Identifiers

Aliases, EC-PTP, PCPTP1, PTP-SL, PTPBR7, PTPRQ, protein tyrosine phosphatase, receptor type R, protein tyrosine phosphatase receptor type R

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 12 (human)

Band 12q15 Start 70,638,073 bp

End70,920,738 bp

Gene location ( Mouse )

Chr.Chromosome 10 (mouse)

Band 10|10 D2 Start 115,854,118 bp

End116,110,837 bp

RNA expression pattern

HumanMouse (ortholog)endothelial cell right hemisphere of cerebellum prefrontal cortex entorhinal cortex jejunal mucosa mucosa of transverse colon Brodmann area 46 testicle orbitofrontal cortex cerebellar vermisIleal epithelium zygote secondary oocyte entorhinal cortex perirhinal cortex lobe of cerebellum CA3 field jejunum transitional epithelium of urinary bladder lumbar spinal ganglion

Human Mouse (ortholog)

endothelial cell right hemisphere of cerebellum prefrontal cortex entorhinal cortex jejunal mucosa mucosa of transverse colon Brodmann area 46 testicle orbitofrontal cortex cerebellar vermisIleal epithelium zygote secondary oocyte entorhinal cortex perirhinal cortex lobe of cerebellum CA3 field jejunum transitional epithelium of urinary bladder lumbar spinal ganglion

endothelial cell right hemisphere of cerebellum prefrontal cortex entorhinal cortex jejunal mucosa mucosa of transverse colon Brodmann area 46 testicle orbitofrontal cortex cerebellar vermis

Ileal epithelium zygote secondary oocyte entorhinal cortex perirhinal cortex lobe of cerebellum CA3 field jejunum transitional epithelium of urinary bladder lumbar spinal ganglion

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Protein tyrosine phosphatase receptor-type R is an enzyme that in humans is encoded by the PTPRR gene.

Function

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domains, and thus represents a receptor-type PTP. The similar gene predominantly expressed in mouse brain was found to associate with, and thus regulate the activity and cellular localization of MAP kinases. The rat counterpart of this gene was reported to be regulated by the nerve growth factor, which suggested the function of this gene in neuronal growth and differentiation.

Interactions

PTPRR has been shown to interact with MAPK7.

PTPRR

Function

Interactions

Further reading