Poliovirus receptor-related 2

NECTIN2

Available structuresPDBOrtholog search:List of PDB id codes, , ,

Available structures

PDBOrtholog search:

List of PDB id codes, , ,

List of PDB id codes

, , ,

Identifiers

Aliases, CD112, HVEB, PRR2, PVRR2, PVRL2, nectin cell adhesion molecule 2

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 19 (human)

Band 19q13.32 Start 44,846,175 bp

End44,889,223 bp

Gene location ( Mouse )

Chr.Chromosome 7 (mouse)

Band 7 A3|7 9.94 cM Start 19,450,569 bp

End19,484,408 bp

RNA expression pattern

HumanMouse (ortholog)stromal cell of endometrium olfactory zone of nasal mucosa apex of heart right lobe of liver gallbladder right testis left adrenal cortex body of stomach mucosa of transverse colon upper lobe of left lungyolk sac transitional epithelium of urinary bladder Ileal epithelium decidua gastrula lumbar spinal ganglion endothelial cell of lymphatic vessel duodenum epiblast crypt of lieberkuhn of small intestine

Human Mouse (ortholog)

stromal cell of endometrium olfactory zone of nasal mucosa apex of heart right lobe of liver gallbladder right testis left adrenal cortex body of stomach mucosa of transverse colon upper lobe of left lungyolk sac transitional epithelium of urinary bladder Ileal epithelium decidua gastrula lumbar spinal ganglion endothelial cell of lymphatic vessel duodenum epiblast crypt of lieberkuhn of small intestine

yolk sac transitional epithelium of urinary bladder Ileal epithelium decidua gastrula lumbar spinal ganglion endothelial cell of lymphatic vessel duodenum epiblast crypt of lieberkuhn of small intestine

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Poliovirus receptor-related 2 (PVRL2), also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), is a human plasma membrane glycoprotein.

Function

This gene encodes a single-pass type I membrane glycoprotein with two Ig-like C2-type domains and an Ig-like V-type domain. This protein is one of the plasma membrane components of adherens junctions. It also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in this gene have been associated with differences in the severity of multiple sclerosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

External links

at the U.S. National Library of MedicineMedical Subject Headings(MeSH)
Overview of all the structural information available in thePDBforUniProt:(Human Nectin-2) at thePDBe-KB.
Overview of all the structural information available in thePDBforUniProt:(Mouse Nectin-2) at thePDBe-KB.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

Poliovirus receptor-related 2

Function

See also

Further reading

External links