Pertine
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The pertines, also known as phenylpiperazinylethylindoles, are a group of antipsychotics of the cyclized tryptamine and phenylpiperazine families that includes the following drugs:
- Alpertine (WIN-31665)
- Milipertine (WIN-18935)
- Oxypertine (WIN-18501)
- Solypertine (WIN-18413)
Oxypertine is known to show high affinity for the serotonin 5-HT2 and dopamine D2 receptors (Ki = 8.6nM and 30nM, respectively) and to also act as a catecholamine depleting agent. Oxypertine, milipertine, and solypertine all antagonize the behavioral effects of tryptamine, a serotonin receptor agonist, and apomorphine, a dopamine receptor agonist, in animals.
Some of the pertines, like milipertine and solypertine, are notable in containing an NBOMe-like moiety.
The pertines were developed and initially described in the 1960s and 1970s.