Protein AATF

Protein AATF, also known as apoptosis-antagonizing transcription factor is a protein that in humans is encoded by the AATF gene.

Function

The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis.

Interactions

Protein AATF has been shown to interact with:

• PAWR,
• POLR2J,
• Retinoblastoma protein, and
• Transcription factor Sp1.

Further reading

External links

• at the U.S. National Library of MedicineMedical Subject Headings(MeSH)
• human gene location in theUCSC Genome Browser.
• human gene details in theUCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.