Pup Creek is a stream in Daviess County, Kentucky, in the United States. It is a tributary of the Ohio River.

Pup Creek was so named from an incident when pioneers drowned puppies in this stream.

See also

37°50′03″N 87°02′38″W/37.8342164°N 87.0438848°W/ 37.8342164; -87.0438848