RASGRF2

Identifiers

Aliases, GRF2, RAS-GRF2, Ras protein specific guanine nucleotide releasing factor 2

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 5 (human)

Band 5q14.1 Start 80,960,363 bp

End81,230,162 bp

Gene location ( Mouse )

Chr.Chromosome 13 (mouse)

Band 13 C3|13 47.43 cM Start 92,028,519 bp

End92,268,164 bp

RNA expression patternHumanMouse (ortholog)middle temporal gyrus Brodmann area 23 endothelial cell sural nerve Brodmann area 46 prefrontal cortex corpus callosum superior frontal gyrus C1 segment occipital lobeventromedial nucleus olfactory tubercle neural layer of retina arcuate nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus substantia nigra superior frontal gyrus dentate gyrus of hippocampal formation granule cell ventral tegmental arean/a

RNA expression pattern

HumanMouse (ortholog)middle temporal gyrus Brodmann area 23 endothelial cell sural nerve Brodmann area 46 prefrontal cortex corpus callosum superior frontal gyrus C1 segment occipital lobeventromedial nucleus olfactory tubercle neural layer of retina arcuate nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus substantia nigra superior frontal gyrus dentate gyrus of hippocampal formation granule cell ventral tegmental area

Human Mouse (ortholog)

middle temporal gyrus Brodmann area 23 endothelial cell sural nerve Brodmann area 46 prefrontal cortex corpus callosum superior frontal gyrus C1 segment occipital lobeventromedial nucleus olfactory tubercle neural layer of retina arcuate nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus substantia nigra superior frontal gyrus dentate gyrus of hippocampal formation granule cell ventral tegmental area

middle temporal gyrus Brodmann area 23 endothelial cell sural nerve Brodmann area 46 prefrontal cortex corpus callosum superior frontal gyrus C1 segment occipital lobe

ventromedial nucleus olfactory tubercle neural layer of retina arcuate nucleus paraventricular nucleus of hypothalamus dorsomedial hypothalamic nucleus substantia nigra superior frontal gyrus dentate gyrus of hippocampal formation granule cell ventral tegmental area

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene.

RAS (MIM 190020) GTPases cycle between an inactive GDP-bound state and an active GTP-bound state. Guanine-nucleotide exchange factors (GEFs), such as RASGRFs, stimulate the conversion of the GDP-bound form into the active form.[supplied by OMIM]

Variations in this gene has been shown to be linked to the propensity to binge drink by teenagers.

RASGRF2

Further reading