RBX1

RING-box protein 1 is a protein that in humans is encoded by the RBX1 gene.

Function

This gene encodes an evolutionarily conserved protein that interacts with cullins. The protein plays a unique role in the ubiquitination reaction by heterodimerizing with cullin-1 to catalyze ubiquitin polymerization. It also may be involved in the regulation of protein turn-over.

Interactions

RBX1 has been shown to interact with:

• CAND1,
• CUL1,
• CUL2,
• CUL4A,
• CUL5
• CUL7,
• DCUN1D1, and
• P70-S6 Kinase 1.

Further reading