CELSR3

Identifiers

Aliases, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1, ADGRC3, cadherin EGF LAG seven-pass G-type receptor 3

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 3 (human)

Band 3p21.31 Start 48,636,463 bp

End48,662,886 bp

Gene location ( Mouse )

Chr.Chromosome 9 (mouse)

Band 9|9 F2 Start 108,703,519 bp

End108,730,168 bp

RNA expression patternHumanMouse (ortholog)right hemisphere of cerebellum ganglionic eminence pituitary gland paraflocculus of cerebellum Brodmann area 10 cerebellar vermis anterior pituitary right frontal lobe postcentral gyrus Region I of hippocampus propercerebellar cortex hypothalamus olfactory bulb ganglionic eminence primary visual cortex superior frontal gyrus striatum of neuraxis granulocyte layer of retina neural layer of retinan/a

RNA expression pattern

HumanMouse (ortholog)right hemisphere of cerebellum ganglionic eminence pituitary gland paraflocculus of cerebellum Brodmann area 10 cerebellar vermis anterior pituitary right frontal lobe postcentral gyrus Region I of hippocampus propercerebellar cortex hypothalamus olfactory bulb ganglionic eminence primary visual cortex superior frontal gyrus striatum of neuraxis granulocyte layer of retina neural layer of retina

Human Mouse (ortholog)

right hemisphere of cerebellum ganglionic eminence pituitary gland paraflocculus of cerebellum Brodmann area 10 cerebellar vermis anterior pituitary right frontal lobe postcentral gyrus Region I of hippocampus propercerebellar cortex hypothalamus olfactory bulb ganglionic eminence primary visual cortex superior frontal gyrus striatum of neuraxis granulocyte layer of retina neural layer of retina

cerebellar cortex hypothalamus olfactory bulb ganglionic eminence primary visual cortex superior frontal gyrus striatum of neuraxis granulocyte layer of retina neural layer of retina

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Cadherin EGF LAG seven-pass G-type receptor 3 is a protein that in humans is encoded by the CELSR3 gene.

The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.

External links

Human genome location and gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

CELSR3

See also

Further reading

External links