RNF40

Identifiers

Aliases, BRE1B, RBP95, STARING, ring finger protein 40

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 16 (human)

Band 16p11.2 Start 30,761,745 bp

End30,776,307 bp

Gene location ( Mouse )

Chr.Chromosome 7 (mouse)

Band 7|7 F3 Start 127,187,939 bp

End127,203,971 bp

RNA expression pattern

HumanMouse (ortholog)ventricular zone left testis right testis ganglionic eminence mucosa of transverse colon islet of Langerhans right lobe of thyroid gland granulocyte sural nerve right hemisphere of cerebellumgranulocyte spermatid spermatocyte neural layer of retina zygote ventricular zone lip muscle of thigh dentate gyrus of hippocampal formation granule cell esophagus

Human Mouse (ortholog)

ventricular zone left testis right testis ganglionic eminence mucosa of transverse colon islet of Langerhans right lobe of thyroid gland granulocyte sural nerve right hemisphere of cerebellumgranulocyte spermatid spermatocyte neural layer of retina zygote ventricular zone lip muscle of thigh dentate gyrus of hippocampal formation granule cell esophagus

ventricular zone left testis right testis ganglionic eminence mucosa of transverse colon islet of Langerhans right lobe of thyroid gland granulocyte sural nerve right hemisphere of cerebellum

granulocyte spermatid spermatocyte neural layer of retina zygote ventricular zone lip muscle of thigh dentate gyrus of hippocampal formation granule cell esophagus

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase BRE1B is an enzyme that in humans is encoded by the RNF40 gene.

Function

The protein encoded by this gene contains a RING finger, a motif known to be involved in protein-protein and protein-DNA interactions. This protein was reported to interact with the tumor suppressor protein RB1. Studies of the rat counterpart suggested that this protein may function as an E3 ubiquitin-protein ligase, and facilitate the ubiquitination and degradation of syntaxin 1, which is an essential component of the neurotransmitter release machinery.

Interactions

RNF40 has been shown to interact with STX1A.

RNF40

Function

Interactions

Further reading