Repetin

RPTN

Identifiers

Aliases, Repetin

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 1 (human)

Band 1q21.3 Start 152,153,595 bp

End152,159,228 bp

Gene location ( Mouse )

Chr.Chromosome 3 (mouse)

Band 3|3 F2.1 Start 93,301,006 bp

End93,306,749 bp

RNA expression patternHumanMouse (ortholog)gums gingival epithelium tongue body of tongue superior surface of tongue skin of leg sperm amniotic fluid epithelium of nasopharynx skin of hipesophagus superior surface of tongue lip molar mucous cell of stomach sexually immature organism skin of abdomen skin of back cervix skin of external earn/a

RNA expression pattern

HumanMouse (ortholog)gums gingival epithelium tongue body of tongue superior surface of tongue skin of leg sperm amniotic fluid epithelium of nasopharynx skin of hipesophagus superior surface of tongue lip molar mucous cell of stomach sexually immature organism skin of abdomen skin of back cervix skin of external ear

Human Mouse (ortholog)

gums gingival epithelium tongue body of tongue superior surface of tongue skin of leg sperm amniotic fluid epithelium of nasopharynx skin of hipesophagus superior surface of tongue lip molar mucous cell of stomach sexually immature organism skin of abdomen skin of back cervix skin of external ear

gums gingival epithelium tongue body of tongue superior surface of tongue skin of leg sperm amniotic fluid epithelium of nasopharynx skin of hip

esophagus superior surface of tongue lip molar mucous cell of stomach sexually immature organism skin of abdomen skin of back cervix skin of external ear

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Repetin is an extracellular matrix protein expressed in the epidermis. In humans it is encoded by the RPTN gene. Repetin is part of the S100 fused-type protein family and contains an EF hand structural domain.

It functions in the cornified cell envelope formation. It is a multifunctional epidermal matrix protein. RPTN reversibly binds calcium.

RPTN is 5,634 bases long. It starts 152,126,071 base pairs from pter. It ends 152,131,704 base pairs from pter. It has a minus strand orientation.

RPTN is one of the genes that differ between present-day humans and Neanderthals. RPTN helps protect skin cells, and since the Neanderthals were missing this protein, the Neanderthals were better adapted to the cold, but less so to disease.