Repulsive guidance molecule
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Repulsive guidance molecules (RGMs) are members of a three gene family (in vertebrates) composed of RGMa, RGMb, and RGMc (also called hemojuvelin). RGMa has been implicated to play an important role in the developing brain and in the scar tissue that forms after a brain injury. For example, RGMa helps guide retinal ganglion cell (RGC) axons to the tectum in the midbrain. It has also been demonstrated that after induced spinal cord injury RGMa accumulates in the scar tissue around the lesion. Further research has shown that RGMa is an inhibitor of axonal outgrowth. Taken together, these findings highlight the importance of RGMa in axonal guidance and outgrowth.
Family members
| RGM domain family, member A | ||
|---|---|---|
| RGM domain family, member AIdentifiersSymbolRGMAAlt. symbolsRGMNCBI geneHGNCOMIMRefSeqUniProtOther dataLocusChr. 15Search forStructuresDomains | RGM domain family, member BIdentifiersSymbolRGMBAlt. symbolsDRAGONNCBI geneHGNCOMIMRefSeqUniProtOther dataLocusChr. 5Search forStructuresDomains | hemochromatosis type 2IdentifiersSymbolHFE2Alt. symbolsRGMC, HJV, hemojuvelinNCBI geneHGNCOMIMRefSeqUniProtOther dataLocusChr. 1Search forStructuresDomains |
| Identifiers | ||
| Symbol | RGMA | |
| Alt. symbols | RGM | |
| NCBI gene | ||
| HGNC | ||
| OMIM | ||
| RefSeq | ||
| UniProt | ||
| Other data | ||
| Locus | Chr. 15 | |
| Search forStructuresDomains | ||
| Search for | ||
| Structures | ||
| Domains | ||
| RGM domain family, member B | ||
| Identifiers | ||
| Symbol | RGMB | |
| Alt. symbols | DRAGON | |
| NCBI gene | ||
| HGNC | ||
| OMIM | ||
| RefSeq | ||
| UniProt | ||
| Other data | ||
| Locus | Chr. 5 | |
| Search forStructuresDomains | ||
| Search for | ||
| Structures | ||
| Domains | ||
| hemochromatosis type 2 | ||
| Identifiers | ||
| Symbol | HFE2 | |
| Alt. symbols | RGMC, HJV, hemojuvelin | |
| NCBI gene | ||
| HGNC | ||
| OMIM | ||
| RefSeq | ||
| UniProt | ||
| Other data | ||
| Locus | Chr. 1 | |
| Search forStructuresDomains | ||
| Search for | ||
| Structures | ||
| Domains |