SEC22B

Available structuresPDBOrtholog search:List of PDB id codes, , ,

Available structures

PDBOrtholog search:

List of PDB id codes, , ,

List of PDB id codes

, , ,

Identifiers

Aliases, ERS-24, SEC22L1, SEC22 homolog B, vesicle trafficking protein (gene/pseudogene), SEC22 homolog B, vesicle trafficking protein

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 1 (human)

Band 1p12 Start 120,150,898 bp

End120,176,520 bp

Gene location ( Mouse )

Chr.Chromosome 3 (mouse)

Band 3|3 F2.2 Start 97,808,506 bp

End97,830,592 bp

RNA expression patternHumanMouse (ortholog)Achilles tendon body of pancreas islet of Langerhans stromal cell of endometrium anterior pituitary epithelium of colon rectum monocyte left adrenal gland Descending thoracic aortacumulus cell endocardial cushion neural layer of retina yolk sac molar lacrimal gland islet of Langerhans calvaria primitive streak seminal vesiculan/a

RNA expression pattern

HumanMouse (ortholog)Achilles tendon body of pancreas islet of Langerhans stromal cell of endometrium anterior pituitary epithelium of colon rectum monocyte left adrenal gland Descending thoracic aortacumulus cell endocardial cushion neural layer of retina yolk sac molar lacrimal gland islet of Langerhans calvaria primitive streak seminal vesicula

Human Mouse (ortholog)

Achilles tendon body of pancreas islet of Langerhans stromal cell of endometrium anterior pituitary epithelium of colon rectum monocyte left adrenal gland Descending thoracic aortacumulus cell endocardial cushion neural layer of retina yolk sac molar lacrimal gland islet of Langerhans calvaria primitive streak seminal vesicula

Achilles tendon body of pancreas islet of Langerhans stromal cell of endometrium anterior pituitary epithelium of colon rectum monocyte left adrenal gland Descending thoracic aorta

cumulus cell endocardial cushion neural layer of retina yolk sac molar lacrimal gland islet of Langerhans calvaria primitive streak seminal vesicula

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Vesicle-trafficking protein SEC22b is a protein that in humans is encoded by the SEC22B gene.

Function

The protein encoded by this gene is a member of the SEC22 family of vesicle trafficking proteins. It associates with other SNARE proteins to form a SNARE complex and it is thought to play a role in the ER-Golgi protein trafficking. It is required for platelet alpha-granule biogenesis in megakaryocytes and is essential for the elongated morphology of endothelial cell Weibel-Palade bodies. This protein has strong similarity to Mus musculus and Cricetulus griseus proteins. There is evidence for use of multiple polyadenylation sites for the transcript. SEC22B has been shown to interact with syntaxin 18 and syntaxin 5.

SEC22B

Function

Further reading