SEPT6

SEPTIN6

Available structuresPDBOrtholog search:List of PDB id codes

Available structures

PDBOrtholog search:

List of PDB id codes

Identifiers

Aliases, SEP2, SEPT2, septin 6, SEPT6

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.X chromosome (human)

Band Xq24 Start 119,615,724 bp

End119,693,370 bp

Gene location ( Mouse )

Chr.X chromosome (mouse)

Band X|X A3.3 Start 36,174,979 bp

End36,255,447 bp

RNA expression pattern

HumanMouse (ortholog)thymus lymph node granulocyte right adrenal cortex appendix left adrenal gland left adrenal cortex blood bone marrow cell spleenbarrel cortex lumbar spinal ganglion facial motor nucleus habenula thymus medial geniculate nucleus medial dorsal nucleus substantia nigra motor neuron blood

Human Mouse (ortholog)

thymus lymph node granulocyte right adrenal cortex appendix left adrenal gland left adrenal cortex blood bone marrow cell spleenbarrel cortex lumbar spinal ganglion facial motor nucleus habenula thymus medial geniculate nucleus medial dorsal nucleus substantia nigra motor neuron blood

thymus lymph node granulocyte right adrenal cortex appendix left adrenal gland left adrenal cortex blood bone marrow cell spleen

barrel cortex lumbar spinal ganglion facial motor nucleus habenula thymus medial geniculate nucleus medial dorsal nucleus substantia nigra motor neuron blood

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Septin-6 is a protein that in humans is encoded by the SEPT6 gene.

Function

This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.

Clinical significance

One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins.

Interactions

SEPT6 has been shown to interact with SEPT2.

SEPT6

Function

Clinical significance

Interactions

Further reading