SEPT8

SEPTIN8

Identifiers

Aliases, SEP2, septin 8, SEPT8

External IDsOMIM: ; MGI: ; HomoloGene: ; GeneCards: ; OMA:

Gene location ( Human )

Chr.Chromosome 5 (human)

Band 5q31.1 Start 132,750,819 bp

End132,807,241 bp

Gene location ( Mouse )

Chr.Chromosome 11 (mouse)

Band 11 B1.3|11 31.96 cM Start 53,410,084 bp

End53,440,392 bp

RNA expression patternHumanMouse (ortholog)middle temporal gyrus C1 segment Brodmann area 23 endothelial cell corpus callosum inferior ganglion of vagus nerve postcentral gyrus entorhinal cortex subthalamic nucleus right frontal lobefacial motor nucleus visual cortex primary visual cortex superior frontal gyrus interventricular septum cerebellar cortex Region I of hippocampus proper primary motor cortex anterior horn of spinal cord dentate gyrus of hippocampal formation granule celln/a

RNA expression pattern

HumanMouse (ortholog)middle temporal gyrus C1 segment Brodmann area 23 endothelial cell corpus callosum inferior ganglion of vagus nerve postcentral gyrus entorhinal cortex subthalamic nucleus right frontal lobefacial motor nucleus visual cortex primary visual cortex superior frontal gyrus interventricular septum cerebellar cortex Region I of hippocampus proper primary motor cortex anterior horn of spinal cord dentate gyrus of hippocampal formation granule cell

Human Mouse (ortholog)

middle temporal gyrus C1 segment Brodmann area 23 endothelial cell corpus callosum inferior ganglion of vagus nerve postcentral gyrus entorhinal cortex subthalamic nucleus right frontal lobefacial motor nucleus visual cortex primary visual cortex superior frontal gyrus interventricular septum cerebellar cortex Region I of hippocampus proper primary motor cortex anterior horn of spinal cord dentate gyrus of hippocampal formation granule cell

middle temporal gyrus C1 segment Brodmann area 23 endothelial cell corpus callosum inferior ganglion of vagus nerve postcentral gyrus entorhinal cortex subthalamic nucleus right frontal lobe

facial motor nucleus visual cortex primary visual cortex superior frontal gyrus interventricular septum cerebellar cortex Region I of hippocampus proper primary motor cortex anterior horn of spinal cord dentate gyrus of hippocampal formation granule cell

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsSpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

Septin-8 is a protein that in humans is encoded by the SEPT8 gene.

Function

SEPT8 is a member of the highly conserved septin family. Septins are 40- to 60-kD GTPases that assemble as filamentous scaffolds. They are involved in the organization of submembranous structures, in neuronal polarity, and in vesicle trafficking.

Interactions

SEPT8 has been shown to interact with PFTK1 and SEPT5.

SEPT8

Function

Interactions

Further reading