SIAH2

Identifiers

Aliases, hSiah2, siah E3 ubiquitin protein ligase 2

External IDsOMIM: ; MGI: ; GeneCards:

Available structuresPDBOrtholog search:List of PDB id codes

Available structures

PDBOrtholog search:

List of PDB id codes

Enzyme activityEC #BRENDA ExPASy KEGG MetaCyc

Enzyme activity

EC # BRENDA ExPASy KEGG MetaCyc

Gene location ( Human )

Chr.Chromosome 3 (human)

Band 3q25.1 Start 150,741,125 bp

End150,763,477 bp

Gene location ( Mouse )

Chr.Chromosome 3 (mouse)

Band 3 D|3 28.68 cM Start 58,582,359 bp

End58,599,821 bp

RNA expression patternHumanMouse (ortholog)right adrenal cortex left adrenal gland left adrenal cortex monocyte ectocervix right lobe of liver blood canal of the cervix bone marrow stromal cell of endometriumsecondary oocyte zygote primary oocyte seminiferous tubule spermatid olfactory epithelium ankle joint parotid gland right kidney islet of Langerhansn/a

RNA expression pattern

HumanMouse (ortholog)right adrenal cortex left adrenal gland left adrenal cortex monocyte ectocervix right lobe of liver blood canal of the cervix bone marrow stromal cell of endometriumsecondary oocyte zygote primary oocyte seminiferous tubule spermatid olfactory epithelium ankle joint parotid gland right kidney islet of Langerhans

Human Mouse (ortholog)

right adrenal cortex left adrenal gland left adrenal cortex monocyte ectocervix right lobe of liver blood canal of the cervix bone marrow stromal cell of endometriumsecondary oocyte zygote primary oocyte seminiferous tubule spermatid olfactory epithelium ankle joint parotid gland right kidney islet of Langerhans

right adrenal cortex left adrenal gland left adrenal cortex monocyte ectocervix right lobe of liver blood canal of the cervix bone marrow stromal cell of endometrium

secondary oocyte zygote primary oocyte seminiferous tubule spermatid olfactory epithelium ankle joint parotid gland right kidney islet of Langerhans

n/a

Gene ontologyMolecular functionCellular componentBiological processSources: /

Gene ontology

Molecular function

Cellular component

Biological process

Sources: /

OrthologsDatabasesNCBI: ; OMA:SpeciesHumanMouseEntrez Ensembl UniProtRefSeq (mRNA)RefSeq (protein)Location (UCSC)PubMed search

Orthologs

DatabasesNCBI: ; OMA:

Species Human Mouse

Entrez

Ensembl

UniProt

RefSeq (mRNA)

RefSeq (protein)

Location (UCSC)

PubMed search

Wikidata

View/Edit HumanView/Edit Mouse

E3 ubiquitin-protein ligase SIAH2 is an enzyme that in humans is encoded by the SIAH2 gene.

Function

This gene encodes a protein that is a member of the seven in absentia homolog (SIAH) family. The protein is an E3 ligase and is involved in ubiquitination and proteasome-mediated degradation of specific proteins. The activity of this ubiquitin ligase has been implicated in regulating cellular response to hypoxia.

Interactions

SIAH2 has been shown to interact with PEG10, Synaptophysin, PEG3 and VAV1.

SIAH2

Function

Interactions

Further reading