S-phase kinase-associated protein 1

S-phase kinase-associated protein 1 is an enzyme that in humans is encoded by the SKP1 gene.

This gene encodes a protein that is a member of the SCF ubiquitin ligase protein complex. It binds to F-box proteins (proteins containing an F-box motif), such as cyclin F, S-phase kinase-associated protein 2, and other regulatory proteins involved in ubiquitin dependent proteolysis. The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7.

Interactions

SKP1A has been shown to interact with:

• BTRC,
• CACYBP,
• CDCA3,
• CDK9,
• CUL1,
• FBXL3,
• FBXO4,
• FBXO5,
• FBXO7,
• FBXW2,
• FBXW7, and
• SKP2.

Further reading

External links

• Overview of all the structural information available in the PDB for UniProt: (S-phase kinase-associated protein 1) at the PDBe-KB.